TELURA

Mfd. by :- Mylan (Fulfilled By : Magicine Pharma)

Telura

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Telura 
Generic Name: Lamivudine + Tenofovir disoproxil fumarate + Efavirenz
Manufacturer: Mylan 
Dosage Form: Tablet 
Strength: 300mg/300mg/600mg
Composition: Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg) + Efavirenz (600mg)
Indication: HIV
Packaging: 30 tablet (30 / strip)
Storage: Store at room temperature

Overview 

Telura (Lamivudine + Tenofovir disoproxil fumarate + Efavirenz) tablet is a combination of three antiretroviral medications. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication belongs to a class of medication known as nucleoside reverse transcriptase inhibitors (NRTIs). Telura tablet boosts your immune system to fight against infection and prevents the virus from multiplying. It is important to take this medicine as prescribed by your healthcare provider. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor.

Pharmacodynamics

Lamivudine (Telura):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) to disrupt viral DNA synthesis. It can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.

Tenofovir Disoproxil Fumarate (Telura):- is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate. It inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5′-triphosphate and, after incorporation into DNA, by DNA chain termination. 

Efavirenz (Telura):- belongs to the NNRTI (non-nucleoside reverse transcriptase inhibitors) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs (reverse transcriptase inhibitors) inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme that transcribes viral RNA into DNA. It is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class. 

Usage 

Telura tablet is a combination of three anti-HIV medicines: Lamivudine, Tenofovir disoproxil fumarate, and Efavirenz. This medication is not a permanent cure for HIV infection. It only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. The recommended dose of Telura medicine is decided by a doctor according to your previous medical condition and response to the treatment. If you experience any signs and symptoms while receiving the Telura tablet, inform your doctor immediately.

Interactions 

Telura tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions

  • Amiodarone

  • Tobramycin 

  • Fluconazole

  • Ciprofloxacin 

  • Methotrexate 

  • Aspirin 

  • Cisplatin 

Disease Interactions  

  • Hepatoxicity 

  • CNS disorders

  • Renal dysfunction 

Alcohol Interaction

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindication

  • Do not use this medicine if you are allergic to Lamivudine, Tenofovir disoproxil fumarate, and Efavirenz

  • Telura tablet is not recommended in patients known to be hypersensitive.

Alternate brands

Side effects 

This medicine may cause some common side effects. Discuss the risks and benefits of the Telura tablets with the doctor before starting the treatment.

Common side effects 

  • Headache 

  • Tiredness 

  • Loss of weight

  • Nausea

  • Insomnia

  • Diarrhea

  • Blood in urine

  • Irregular heartbeat

  • Abnormal dream 

  • Fever 

  • Chills 

  • Loss of strength 

  • Fatigue 

  • Sore throat 

  • Unusual weakness 

  • Blurred vision 

  • Indigestion 

  • Constipation

  • Redness of skin

  • Abdominal pain 

  • Heartburn 

  • Muscle pain 

Note - immediately contact your health care provider if any side effects occur.

 

Dosage 

Take this medicine as prescribed by your doctor. Make sure to not skip or stop your regular dosing schedule. 

Missed dose 

  • It is advisable not to miss a dose. If you miss a scheduled dose of Telura tablets, contact your doctor immediately. 

Overdose 

  • In case of an overdose of Telura tablets, the doctor will provide emergency medical treatment.

Warnings 

Before starting treatment with Telura medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use suitable methods of contraception to prevent pregnancy while taking Telura medicine. 

  • Children and adolescents 

    • Telura tablets are not recommended for use in children under the age of 18. 

Warnings for female 

  • Pregnancy

    • Do not use Telura medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy. 

  • Breastfeeding

    • This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Telura (Lamivudine + Tenofovir disoproxil fumarate + Efavirenz). 

Precautions 

  • Close monitoring of body fat distribution and body weight is required during treatment with this medicine. 

  • This medication should be used with caution in some patients because it may increase the risk of CNS side effects like drowsiness, hallucinations, etc. 

  • Telura tablet may increase the risk of lactic acidosis.

  • This medication may increase the risk of immune reconstitution syndrome.

Cautions 

  • Do not drive or operate heavy machinery.

  • Do not crush or break the tablet. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication.

 

Q1. What is Telura?

Ans. This is an antiviral medication that prevents the human immunodeficiency virus (HIV) from multiplying in your body. Telura tablet also helps to delay the production of HIV infection and improves the quality of life.

Q2. How does Telura work?

Ans. This medication helps to boost your immune system to fight against infection and also increases the CD4 cell (white blood cells that protect against infection) count in your blood.

Q3. What are the side effects?

Ans. Some common side effects are:- fatigue, sore throat, headache, nausea, taste change, stomach ache, diarrhea, fever, chills, blurred vision, weight loss, abnormal dreams, etc.

Q4. How to take this medicine?

Ans. It is important to take this medicine as prescribed by your healthcare provider. 

Q5.  What are the storage conditions?

Ans. Store this medicine at room temperature. Keep it away from direct heat and light. 

Q6.  What happens if I miss a dose? 

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately.

Q7.  What should I avoid while receiving this medication? 

Ans. Follow your medical practitioner’s advice about any restrictions on food and other activities.

Q8. Can I drive after taking this medicine? 

Ans. Telura tablet may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur.

Q9. What are the self-care tips? 

Ans. Keep yourself hydrated and maintain good nutrition.

Q10. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q11. In what strength is it available? 

Ans. It is available in the strength of 300mg/300mg/600mg. 

Q12. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended during pregnancy.

Q13. Does this medicine affect liver function? 

Ans. Please consult your doctor before consuming this drug.

 

Above Content has been reviewed by Professionals