TRIUMEQ

Mfd. by :- ViiV Healthcare (Fulfilled By : Magicine Pharma)

Triumeq

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Triumeq 
Generic Name: Abacavir + Dolutegravir + Lamivudine
Manufacturer: ViiV healthcare 
Dosage Form: Tablet 
Strength: 600mg/50mg/300mg
Composition: Abacavir (600 mg) + Dolutegravir (50 mg) + Lamivudine (300 mg)
Indication: HIV 
Packaging: 30 tablet
Storage: Store at room temperature 

Overview

Triumeq tablet is a combination of three anti-HIV medicines: Abacavir, Dolutegravir, and  Lamivudine. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication is not a permanent cure for HIV infection. Triumeq only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. It is advised not to change your regular dosing schedule without taking suggestions from your doctor. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.

Pharmacodynamics

Abacavir (Triumeq):- is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). It is phosphorylated to active metabolites that compete for incorporation into viral DNA. They work to inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis.

Dolutegravir (Triumeq):- is an HIV-1 antiviral agent. It works to inhibit HIV integrase and binds to the active site. It blocks the strand transfer step of retroviral DNA integration in the host cell. During the clinical trials, it was indicated that Dolutegravir has a tight binding and longer dissociative half-life.

Lamivudine (Triumeq):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) to disrupt viral DNA synthesis. Lamivudine can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.

Usage 

Triumeq (Abacavir + Dolutegravir + Lamivudine) tablet is a combination of three antiretroviral medications. It is used for the treatment of HIV (human immunodeficiency virus) infection. boosts your immune system to fight against infection and helps to reduce the amount of HIV in your body and improves the quality of life. It is important to take Triumeq tablet as prescribed by your doctor. Do not take this medicine in the wrong way as it may lead to some serious side effects. The recommended dose of Triumeq medication is decided by a doctor according to your previous medical condition and response to the treatment.

Interactions 

Triumeq tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions 

  • Apalutamide 

  • Carbamazepine 

  • Emtricitabine 

  • Kaolin 

  • Leflunomide 

  • Primidone 

Disease Interactions 

  • Pancreatitis 

  • Hepatoxicity 

  • Renal dysfunction

Alcohol Interaction

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindication

  • Do not use this medicine if you are allergic to Abacavir, Dolutegravir, and Lamivudine

  • Triumeq tablet is not recommended in patients known to be hypersensitive.

 

Side effects

This medicine may cause some side effects. Discuss the risks and benefits of the Triumeq tablets with the doctor before starting the treatment.

  • Dizziness

  • Unusual sweating

  • Skin rash

  • Itching

  • Indigestion 

  • Constipation

  • Redness of skin

  • Headache

  • Taste change

  • Blurred vision

  • Confusion

  • Weight loss

  • Sweating

  • Mood changes 

  • Nausea

  • Fever

  • Chills

  • Nightmare 

  • Stomach ache

  • Diarrhea

  • Blood in urine

  • Irregular heartbeat

  • Abnormal dream 

  • Confusion 

  • Muscle pain

Note - immediately contact your health care provider if any side effects occur.

 

Dosage 

Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule. 

Missed dose 

  • It is advisable not to miss a dose. If you miss a scheduled dose of Triumeq tablets, contact your doctor immediately. 

Overdose 

  • In case of an overdose of Triumeq tablets, the doctor will provide emergency medical treatment.

Warnings 

Before starting treatment with Triumeq medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use suitable methods of contraception to prevent pregnancy while taking Triumeq medicine. 

  • Children and adolescents 

    • Triumeq tablets are not recommended for use in children under the age of 18. 

Warnings for female 

  • Pregnancy

    • Do not use Triumeq medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy. 

  • Breastfeeding

    • This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with

Precautions 

  • Close monitoring of kidney and liver function is required during treatment with this medicine. 

  • This medication may increase the risk of immune reconstitution syndrome.

  • Inform your doctor if you experience any side effects like- nausea, insomnia, fever, sore throat, headache, abnormal dream, anxiety, etc.

  • Triumeq tablet increases the risk of lactic acidosis.

Cautions

  • Do not drive or operate heavy machinery.

  • Do not crush or break the tablet. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication.

Q1. What is Triumeq (Abacavir + Dolutegravir + Lamivudine)?

Ans. Triumeq tablet is an antiviral medication that prevents the human immunodeficiency virus (HIV) from multiplying in your body. Triumeq tablet also helps to delay the production of HIV infection and improves the quality of life.

Q2.  What are the side effects?

Ans. Some common side effects are:- fatigue, headache, nausea, taste change, stomach ache, diarrhea, fever, chills, blurred vision, weight loss, abnormal dreams, etc.

Q3. How does Triumeq (Abacavir + Dolutegravir + Lamivudine) work?

Ans. This medication helps to boost your immune system to fight against infection. It also helps to delay the production of HIV infection. 

Q4. What happens if I miss a dose? 

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately.

Q5.  In what strength is it available? 

Ans. It is available in the strength of 600mg/50mg/300mg.

Q6. Can I drive after taking this medicine? 

Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur.

Q7. How to take this medicine?

Ans. It is important to take this medicine as prescribed by your doctor. 

Q8. What should I avoid while receiving this medication? 

Ans. Follow your doctor’s advice about any restrictions on food and other activities.

Q9. What are the self-care tips? 

Ans. Keep yourself hydrated and maintain good nutrition.

Q10. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q11. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended during pregnancy.

Q12.   What are the storage conditions?

Ans. Store this medicine at room temperature. Keep it away from direct heat and light. 

Q13. Does this medicine affect liver function? 

Ans. Please consult your doctor before consuming this drug.

Above Content has been reviewed by Professionals