TRUSTIVA

Mfd. by :- Hetero (Fulfilled By : Magicine Pharma)

Trustiva

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Trustiva 
Generic Name: Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz
Manufacturer: Hetero  
Dosage Form: Tablet 
Strength: 200mg, 300mg and 600mg
Composition: Emtricitabine(200mg) + Tenofovir disoproxil fumarate(300mg) + Efavirenz(600mg)
Indication: HIV 
Storage: Store at room temperature 

Overview 

Trustiva (Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz) tablet is used in the treatment of HIV (human immunodeficiency virus). This medication boosts your immune system to fight against infection and prevents the virus from multiplying. Trustiva tablet increases the CD4 cell (white blood cells that protect against infection) count in your blood.  It is advisable not to change your regular dosing schedule without taking suggestions from your doctor. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.

Pharmacodynamics 

Emtricitabine (Trustiva):- a synthetic nucleoside analog of cytidine, is phosphorylated by cellular enzymes to form Emtricitabine (Trustiva) 5'-triphosphate. Emtricitabine inhibits the activity of the HIV-1 reverse transcriptase (RT) by competing with the natural substrate deoxycytidine 5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.

Tenofovir Disoproxil Fumarate (Trustiva):- is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5'-triphosphate and, after incorporation into DNA, by DNA-chain termination.

Efavirenz (Trustiva):- belongs to the NNRTI (non-nucleoside reverse transcriptase inhibitors) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs (reverse transcriptase inhibitors) inhibit the same target, reverse transcriptase enzyme, an essential viral enzyme that transcribes viral RNA into DNA. RTIs bind the enzyme's active site, NNRTIs act allosterically by binding to a distinct site away from the active site known as the NNRTI pocket. Efavirenz is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class. 

Usage 

Trustiva tablet is a combination of three anti-HIV medicines: Emtricitabine, Tenofovir disoproxil fumarate, and Efavirenz. This medication is not a permanent cure for HIV it only prevents the multiplication of infection in human cells. It is important to take this medicine as prescribed by your doctor.  Do not take this medicine in the wrong way as it may lead to some serious side effects. The recommended dose of Trustiva medicine is decided by a doctor according to your previous medical condition and response to the treatment.

Interactions 

Trustiva tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions 

  • Fluconazole

  • Cisplatin 

  • Tobramycin 

  • Gentamicin 

  • Methotrexate 

  • Lamivudine 

  • Ciprofloxacin 

Disease Interactions 

  • Increase in cholesterol levels 

  • Hepatic impairment 

  • CNS orders 

  • Renal dysfunction 

Alcohol Interaction

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindications 

  • Trustiva tablet is not recommended for use in patients with liver disease. 

  • Do not take this medicine if you are allergic to Emtricitabine, Tenofovir disoproxil fumarate, and Efavirenz.

  • Trustiva tablet is not recommended in patients known to be hypersensitive.

  • This medicine is not recommended for use in patients with severe renal impairment. 

Substitutes

  • Teefavir   
  • Teevir 

  • Viraday 

  • Frostavir 

  • Virotrenz 

Side effects 

This medicine may cause some side effects. Discuss the risks and benefits of the Trustiva tablets with the doctor before starting the treatment.

Common side effects

  • Dizziness

  • Unusual sweating

  • Skin rash

  • Itching

  • Indigestion 

  • Constipation

  • Redness of skin

  • Headache

  • Taste change

  • Blurred vision

  • Confusion

  • Weight loss

  • Sweating

  • Mood changes 

  • Nausea

  • Fever

  • Chills

  • Peripheral neuropathy

  • Stomach ache

  • Diarrhea

  • Blood in urine

  • Irregular heartbeat

  • Abnormal dream 

  • Confusion 

Note - immediately contact your health care provider and medical practitioner if any side effects occur.

 

Dosage 

Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule. 

Missed dose 

  • It is advisable not to miss a dose. If you miss a scheduled dose of Trustiva tablets, contact your doctor immediately. 

Overdose 

  • In case of an overdose of Trustiva tablets, the doctor will provide emergency medical treatment.

Warning

Before starting treatment with Trustiva medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use suitable methods of contraception to prevent pregnancy while taking Trustiva medicine. 

  • Children and adolescents 

    • Trustiva tablets are not recommended for use in children under the age of 12. 

Warnings for female 

  • Pregnancy

    • Do not use Trustiva medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy. 

  • Breastfeeding

    • This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Trustiva (Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz). 

Precautions 

  • Trustiva increases the risk of lactic acidosis.

  • This medication should be used with caution in some patients because it may increase the risk of CNS side effects like drowsiness, hallucinations, etc. 

  • Close monitoring of bone mineral density is required during treatment with this medicine. 

  • This medication may increase the risk of immune reconstitution syndrome. 

Cautions 

  • Do not drive or operate heavy machinery.

  • Do not crush or break the tablet. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication.

Q1. What is Trustiva (Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz)?

Ans. Trustiva tablet is an antiviral medication that prevents the human immunodeficiency virus (HIV) from multiplying in your body.

Q2. How to take this medicine?

Ans. It is important to take this medicine as prescribed by your doctor. 

Q3. In what strength is it available? 

Ans. It is available in the strength of 200mg/300mg/600mg. 

Q4. How does Trustiva work?

Ans. This medication helps to boost your immune system to fight against infection. It also helps to delay the production of HIV infection and improves the quality of life. 

Q5. What are the side effects?

Ans. Some common side effects are:- Abnormal dreams, fatigue, sore throat, headache, nausea, taste change, stomach ache, peripheral neuropathy, diarrhea, fever, chills, blurred vision, weight loss, abnormal dreams, etc.

Q6. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q7. What should I avoid while receiving this medication? 

Ans. Follow your doctor’s advice about any restrictions on food and other activities.

Q8. Does this medicine affect liver function? 

Ans. Please consult your doctor before consuming this drug.

Q9. Can I drive after taking this medicine? 

Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur. 

Q10. What happens if I miss a dose? 

Ans. If you miss a scheduled dose of Trustiva tablets, contact your doctor immediately.

Q11. What are the storage conditions?

Ans. Store this medicine at room temperature. Keep it away from direct heat and light. 

Q12.  Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended during pregnancy.

Q13. What are the self-care tips? 

Ans. Maintain good nutrition and keep yourself hydrated.

Above Content has been reviewed by Professionals