XOVOLTIB 40MG TABLET

Mfd. by :- Boehringer Ingelhein (Fulfilled By : Magicine Pharma)

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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DESCRIPTION

Composition : Afatinib
Manufacturer : Boehringer Ingelhein
Indication : Lung Cancer
Packaging : Tablet 28
Dosage Form : Tablet

PACKAGE

40mg

30mg

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Brand name – Xovoltib

Generic name – Afatinib

Manufacturer – Boehringer Ingelhein

Strength – 40mg/30mg

Dosage Form – Tablet

Composition – Afatinib

Indication – Lung Cancer

Storage – at room temperature

Overview XOVOLTIB 40MG TABLET

Xovoltib is a chemotherapy medicine that is used to treat non-small cell lung cancer. Afatinib is the generic name of this medication. It is a 4-anilinoquinazoline tyrosine kinase that has antineoplastic activities.

Pharmacodynamics

Xovoltib is used as a first-line treatment for non-small cell lung cancer which has EGFR mutations. EGFR stands for epidermal growth factor receptor. Some mutations that occur in EGFR stimulate cell proliferation in lung cancer. Xovoltib binds irreversibly to EGFR and as a result, down-regulates its signals. It furthermore stops cell proliferation and shrinking of the tumours. In addition, it blocks phosphorylation and triggers cell death in the cancer cells.

Usage

Xovoltib 40mg tablets or 30 mg tablets are given based on a prescription by the doctor or healthcare provider for the treatment of non-small cell lung cancer (NSCLC). The course and dosage of the medication are decided by the doctor depending on the stage of cancer and the condition of the patient. Xovoltib is an oral tablet that needs to be taken on an empty stomach either one hour before the meal or two hours after the meal. Also, it is advisable to inform the doctor about all the past ailments and allergies before starting the treatment.

Interactions

With medicines

Xovoltib 40mg (30mg) can interact with some other prescription and non-prescription medicines and interfere with each other’s workings or increase the side effects. Inform your doctor if you consume any of these –

Itraconazole
Cyclosporine
Erythromycin
Carbamazepine
Phenytoin
Rifampin
Phenobarbital

With disease

Some diseases may show interactions with. Hence, consult your doctor if you have any of these conditions –

Lung problems
Eyes problems
Cardiovascular conditions
Renal problems
Liver diseases

With alcohol

Interactions of alcohol with Xovoltib are unknown. So, it is advisable to avoid consuming alcohol during the treatment.

Contraindication off Xovoltib

Xovoltib 40mg tablets or Xovoltib 30mg should not be prescribed to patients who show an allergic reaction.

Alternate Brands

Giotrif
Afanat

Dry skin
Loss of appetite
Cracked or swollen lips
Acne
Nose bleeds
Diarrhea
Nausea
Vomiting
Fever
Cough
Nose bleeds
Weight gain
Blisters of skin
Rashes due to sun exposure
Dark coloration of urine
Shortness of breath
Eye pain
Increased bruises
Irregular heart rate
Nail infection
Sensitivity to light
Yellowing of skin and eyes
Painful urination

It is prescribed by the doctor hence, it is advisable to follow the prescription given. Xovoltib 40mg tablets are taken orally once every day on an empty stomach.

Missed dose

It is advisable to avoid missing any doses. In case you miss a dose of Xovoltib 40mg (30mg) consult your doctor immediately.

Overdose

In case of an overdose, contact your doctor or any healthcare provider and seek medical attention immediately. Dizziness, headaches, and vomiting are some of the initial signs of an overdose.

Xovoltib tablets can cause an allergic reaction in some patients. Hence, it is mandatory to read complete information about the tablets before consuming them.
Inform the doctor about the vitamin supplements, herbal medications, and prescription and non-prescription drugs. Some of the medications that can interact are – antifungal, seizures, and HIV medications.
Xovoltib 30mg can harm the fetus hence, it is advisable to avoid pregnancy during and till two weeks after the last dose.
The treatment with Xovoltib tablets increases the sensitivity of the skin therefore it is advisable to avoid sunlight or wear complete covering and sunscreen
Also, avoid breastfeeding while you are taking Xovoltib tablets
Avoid driving and operating heavy machinery and also avoid drinking alcohol during the treatment.
Inform the doctor about the past health conditions –
Lung problems
Eyes problems (dry eyes or if you wear contacts)
Heart conditions
Kidney problems
Liver diseases

Q:- What is Xovoltib?

Ans:- Xovoltib 40mg or 30mg is an anticancer tablet that is primarily used in the treatment of lung cancers.

Q:- How can I take Xovoltib 40mg tablets?

Ans Xovoltib 40mg tablets are taken orally once every day. However, it is advisable to follow the prescription given by the doctor.

Q:- Where to store Xovoltib tablets?

Ans:- It is advisable to store the Xovoltib tablets at room temperature often below 30°C.

Q:- Can I drink alcohol with Xovoltib 30mg?

Ans:- It is advisable to avoid drinking alcohol during the treatment with Xovoltib 30mg tablets even though no interactions of both are known.

Q:- How long is the treatment with Xovoltib 40mg tablets?

Ans:- The doctor or the healthcare provider decides the course of treatment depending on the stage of disease and health of the patient.

Q:- Can I drive after taking Xovoltib tablets?

Ans:- It is advisable to avoid driving and operating heavy machinery as Xovoltib causes dizziness as one of the side effects.

Q:- Is it safe to have a pregnancy during the treatment with Xovoltib?

Ans:- It is advisable to avoid pregnancy during and till two weeks after the treatment since Xovoltib can cause harm to the fetus.

Q:- What is the strength of Xovoltib tablets?

Ans:- Xovoltib is available in 40mg and 30mg strengths. The doctor decides which dose should be prescribed to the patient.

Reference

Afatinib: MedlinePlus Drug Information MedlinePlus. Available at: https://medlineplus.gov/druginfo/meds/a613044.html.

Afatinib Uses, Interactions, Mechanism of Action | DrugBank Online. Available at: https://go.drugbank.com/drugs/DB08916.

Afatinib (oral route) description and brand names (2023) Mayo Clinic. Available at: https://www.mayoclinic.org/drugs-supplements/afatinib-oral-route/description/drg-20061227.