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SOLIRIS 300MG INJECTION (ECULIZUMAB)

Mfd. by :- Alexion Pharmaceuticals (Fulfilled By : Magicine Pharma)

Soliris 300mg Injection (Eculizumab)

SAFE AND SECURE


Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Soliris is a formulation of Eculizumab, a humanized monoclonal antibody. This medicine is used in the treatment of patients diagnosed with myasthenia gravis. This disease is a long-term neuromuscular condition. Eculizumab is also used in the prevention of red blood cell breakdown. It is indicated to patients weighing above 5 kilograms (11 pounds) to treat various blood disorders. Soliris (Eculizumab) is available in the strength of 300mg as injections for intravenous (IV) use only.

Pharmacodynamics

Soliris comprises Eculizumab as its active salt. It is a monoclonal antibody that inhibits the cleavage of complement protein C5 into C5a and C5b, as well as the development of the terminal complement complex C5b-9. Complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria, complement-mediated microangiopathy in atypical hemolytic uremic syndrome, and immune-mediated inflammation and central nervous system damage in neuromyelitis optica spectrum disorder are all prevented by inhibiting this complex.

Interactions 

The following are some interactions of Soliris (Eculizumab) injection with other drugs and diseases. You may require dose modifications.

With medicines

  • Immune globulin
  • Efgartigimod alfa

With diseases

  • Meningococcal infections
  • Infections
  • Progressive multifocal leukoencephalopathy
  • Thrombotic microangiopathy

With alcohol

Soliris (Eculizumab) injection may interact with alcoholic drinks. This may lead to severe effects. Thus, it’s advisable to avoid alcohol consumption.

Contraindications

Soliris (Eculizumab) injection is not indicated for use in the following conditions.

  • Hypersensitivity
  • Allergy to Eculizumab
  • Pregnancy
  • Breastfeeding 

Side Effects of Soliris 300mg Injection

The following are some side effects of Soliris (Eculizumab) injection. Contact your doctor if these events occur for too long or become severe.

  • Bone pain
  • Hoarseness 
  • Constipation 
  • Ear congestion
  • Sneezing 
  • Chills 
  • Nausea 
  • Pale skin
  • Loss of appetite
  • Difficulty in breathing
  • Loss of voice
  • Pounding in the ears
  • Nervousness 
  • Cough 
  • Sore throat
  • Fast heartbeat
  • Fever 
  • Headache 
  • Vomiting 
  • Tarry stools
  • Bladder pain

Soliris (Eculizumab) injection is not indicated for self-use. You can’t take this drug on your own. Your doctor will administer Soliris injection as per a fixed strength. It must be given intravenously (into a vein) after dilution.

Missed dose

If you skip a dose of Soliris (Eculizumab) injection, you must ask your doctor about the best ways to cope with it. Your therapy may require rescheduling.

Overdose

If you overdose on Soliris (Eculizumab) injection, you may experience symptoms like dizziness, fainting, and shortness of breath. Other symptoms may also arise. Consult your doctor immediately.

 

General warnings

  • Inform your doctor about the medicines you already take. You may require dose adjustments concerning your medical record.
  • Soliris (Eculizumab) injection may interact with alcoholic drinks. Thus, it’s advisable to avoid alcohol consumption.
  • During your therapy with this drug, you may develop bacterial infections. Tell your doctor about any new symptom without delay.
  • You may require certain blood tests to monitor the condition and look out for improvements.

Warnings for females

  • Pregnancy
    • During pregnancy, the use of Soliris (Eculizumab) injection may be unsafe. Consult your doctor to know the risks and benefits of this drug.
  • Breastfeeding 
    • During breastfeeding, the use of Soliris (Eculizumab) injection may be unsafe. Either discontinue breastfeeding or know the benefits and risks of this drug.

Cautions 

  • Do not try to self administer this drug. 
  • This medicine may cause dizziness and loss of concentration. It’s advised to avoid driving.
  • Keep Soliris (Eculizumab) injection away from children and pets.
  • Do not overdose or skip a dose during Soliris therapy.

Q1- What is Soliris 300mg Injection (Eculizumab)?

Ans- Soliris (Eculizumab) is used in the treatment of patients diagnosed with myasthenia gravis. It is also used in the prevention of red blood cell breakdown. 

Q2- How to use Soliris 300mg Injection (Eculizumab)?

Ans- Soliris (Eculizumab) injection is not indicated for self-use. You can’t take this drug on your own. Your doctor will administer Soliris injection as per a fixed strength.

Q3- Does Soliris 300mg Injection (Eculizumab) cause any side effects?

Ans- The side effects of Soliris (Eculizumab) injection are vomiting, headache, hives, loss of voice, trouble sleeping, loss of appetite, ear congestion, chills, cough, diarrhea, pounding in the ears, pain in the arms, pale skin, etc.

Q4- What happens if I overdose on Soliris (Eculizumab)?

Ans- If you overdose on Soliris (Eculizumab) injection, you may experience symptoms like dizziness, fainting, and shortness of breath. Other symptoms may also arise.

Q5- Is it safe to use Soliris (Eculizumab) during pregnancy?

Ans- During pregnancy, the use of Soliris (Eculizumab) injection may be unsafe. Consult your doctor to know the risks and benefits of this drug.

Q6- Is it safe to use Soliris 300mg Injection (Eculizumab) during breastfeeding?

Ans- During breastfeeding, the use of Soliris (Eculizumab) injection may be unsafe. Either discontinue breastfeeding or know the benefits and risks of this drug.

Q7- In what form is Soliris 300mg Injection (Eculizumab) available?

Ans- Soliris (Eculizumab) is available in the form of injections.

Q8- In what strength is Soliris 300mg Injection (Eculizumab) available?

Ans- Soliris (Eculizumab) is available in the strength of 300mg.

Q9- Is alcohol consumption safe during the course of Soliris (Eculizumab)?

Ans- Soliris (Eculizumab) injection may interact with alcoholic drinks. This may lead to severe effects. Thus, it’s advisable to avoid alcohol consumption.

Q10- How to store Soliris 300mg Injection (Eculizumab)?

Ans- Store Soliris (Eculizumab) at 2º-8º C.

Above Content has been reviewed by Professionals