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Bronchonib 150mg Tablet

Bronchonib 150mg Tablet

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Salt Composition: Nintedanib (150mg)

Expiry Date: 01/2028

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10 Tablet

About The Product

Used to manage lung fibrosis caused by autoimmune diseases like scleroderma.

Description

Bronchonib 150mg tablet is an anti-fibrotic medicine. It is used in the treatment to manage lung fibrosis which is caused by the disease of scleroderma and non small cell lung cancer.

It contains an active ingredient of Nintedanib formulated as 150mg capsule. It works by inhibiting multiple tyrosine kinases involves in the formation of fibrosis, thereby slowing down the disease progression.

The exact dose and duration is only recommended by the healthcare professional under strict medical conditions.

Indication

Treat lung fibrosis and non small cell lung cancer

Common Side Effects

  • Bronchonib 150mg tablet cause side effects.
  • Some people experience mild and severe symptoms after using the medication.
  • Visit the doctor if any of these symptoms persist: ● Diarrhea ● Nausea ● Vomiting ● Loss of appetite ● Abdominal pain ● High blood pressure ● Headache ● Breathlessness ● Weight loss ● Yellow eyes ● Bronchitis ● Bleeding problems ● Skin ulcer ● Hypertension ● fever

Dosage And Duration

  • Bronchonib 150mg tablet should be taken with food, try to take it the fixed time time everyday.
  • The medication should be taken based on response to the treatment, consume it with whole glass of water, do not crush or chew the tablet.
  • Discuss with the doctor if you experience any of the side effects and if you have concerns about its use.

Mechanism Of Action

Scleroderma is an auto immune disease which causes excessive collagen build up, leading to skin thickening and potential damage to lung.

Bronchonib 150mg tablet slow the progression of scarring (Fibrosis) in the lungs by reduces the activity of pathways that contribute to tissue damage and help to improve breathing and preserving lung function over time.

Safety Advice

Alcohol
It is advisable to limit or avoid alcohol while taking Bronchonib tablet. Alcohol can increase the risk of liver related effects, which is already possible with this medicine.
Driving
Bronchonib 150mg tablet cause dizziness or tiredness, if you feel any unwell or fatigued then avoid driving and operating mechinery.
Pregnancy
Pregnant women should avoid using Bronchonib 150mg tablet as it harm the developing baby.
Kidney
Bronchonib 150mg tablet can generally be used with mild to moderate kidney problems, but caution is required. Severe kidney disease may require special assessment to use. Doctor monitor your condition closely.
Liver
Bronchonib 150mg tablet may affect liver function. Regular liver function test (LFT) is required. People need dose adjustment or close monitoring during the treatment.

Reference

• Roth, G. J., Binder, R., Colbatzky, F., Dallinger, C., Schlenker-Herceg, R., Hilberg, F., ... & Kaiser, R.

(2015). Nintedanib: from discovery to the clinic.

Journal of medicinal chemistry, 58(3), 1053-1063. • Richeldi, L., Du Bois, R. M., Raghu, G., Azuma, A., Brown, K.

K., Costabel, U., ... & Collard, H. R.

(2014). Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis.

New England Journal of Medicine, 370(22), 2071-2082. • Wollin, L., Wex, E., Pautsch, A., Schnapp, G., Hostettler, K. E., Stowasser, S., & Kolb, M.

(2015). Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis.

European Respiratory Journal, 45(5), 1434-1445. • Rangarajan, S., Kurundkar, A., Kurundkar, D., Bernard, K., Sanders, Y. Y., Ding, Q., ... & Thannickal, V.

J. (2016).

Novel mechanisms for the antifibrotic action of nintedanib. American journal of respiratory cell and molecular biology, 54(1), 51-59. • Wind, S., Schmid, U., Freiwald, M., Marzin, K., Lotz, R., Ebner, T., ... & Dallinger, C.

(2019). Clinical pharmacokinetics and pharmacodynamics of nintedanib.

Clinical pharmacokinetics, 58(9), 1131-1147.

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