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28 Tablet
Sofosbuvir and Velpatasvir
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Overview
Two antiviral medications are combined in Sofocure V Tablet. Chronic hepatitis C virus (HCV) infection is treated with this prescription medication. Sofocure V Tablet is classified as a hepatitis medication. The main cause of this disease is an infectious virus that can be transmitted by eating contaminated food, drinking contaminated water, or coming into close contact with an infected person. While Sofocure V is not a medication for HIV or AIDS, it does treat certain genotypes of hepatitis C in certain individuals and can also be used to treat HIV. Together, sofosbuvir and velpatasvir, which are found in Sofocure-V Tablet, prevent the hepatitis C virus from multiplying within your body.
Hepatitis C, Viral Infection
To treat chronic hepatitis C (HCV) infection.
The human body shows undesired symptoms after taking Sofocure V 400mg/100 mg tablet. Usually, they disappear with time as the body adjusts to the medicine. These side effects don't need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.
Some of the common side effects of Sofocure V Tablet are mentioned below:
• Fever
• Nausea
• Joint pain
• Vomiting
• Fatigue
• Abdominal pain
• Poor appetite
• Itching
• Dark yellow urine & stools
• JaundicePale skin
• Unusual tiredness
• Feeling light-headed
• Difficulty breathing
• Cold hands and feet
Before using the Sofocure V Tablet, carefully read the instructions. As prescribed by your physician, take these. With or without food, take it. This will allow for better absorption. Stop taking them and consult your doctor if you experience any negative effects. Oral administration is recommended for Sofocure V 400mg/100mg Tablet, a prescription medication for hepatitis. It is recommended that you speak with your healthcare provider before using this tablet. For maximum advantages, it should be taken daily at the same time.
Sofocure V 400mg/100mg Tablet is a prescription-based Hepatitis medicine used in the treatment of the hepatitis C virus. The active ingredients of the Sofocure V are Sofosbuvir and Velpatasvirwhich belong to the drug class of direct-acting antivirals (DAAs). It is taken orally with or without food as per the doctor's advice. Sofocure V Tablet works by eliminating the virus from the human body. In this way, it prevents the infection from spreading to other parts of the body. The required dosage and duration of the medicine are decided by the doctor. This depends on the type of hepatitis being treated. The doctor will check medical history, age, health condition, and the body's response to the treatment before prescribing this medicine. Taking it in the wrong way or overdosing can cause severe side effects. It may take weeks for patients to notice the benefits of the medicine. So do not stop taking this tablet until your doctor says to do so. Sofocure v is given as a combination therapy with other antiviral medications to treat chronic hepatitis C in adults, and it should not be used alone.
Alcohol
consult your doctor
The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Sofocure V 400mg/100mg Tablet. It is advised to consult your doctor for further information.
Pregnancy
consult your doctor
Sofocure V 400mg/100mg Tablet may be considered unsafe during pregnancy. Please consult your doctor in such a condition.
Breast Feeding
consult your doctor
Sofocure V 400mg/100mg Tablet is probably not safe if you're breastfeeding. Kindly consult your doctor.
Driving
unsafe
It is advisable not to drive or operate heavy machinery as you may feel dizzy after taking Sofocure V 400mg/100mg Tablet.
Kidney
safe if prescribed
Share your medical history with your healthcare expert in case of kidney disease before taking Sofocure V 400mg/100mgTablet.
Liver
safe if prescribed
Inform your doctor before starting Sofocure V 400mg/100mgTablet if you have liver disease to avoid any serious side effects.
It is advised not to miss any scheduled dosage of Sofocure V 400mg/100mg tablet. In case you miss a dose, consult your doctor immediately.
Don't overdose to compensate for the missed one. Contact your doctor or any healthcare provider and seek medical attention immediately in such cases.
• Go for a liver function test once you start the treatment to ensure normal functioning of the organ.
• Do not share your medicine with other people, as some medicines treat specific genotypes of Hepatitis.
• Some Hepatitis medicines are given in combination with other antiviral drugs. So, it is advised not to use them alone.
• Hepatitis medicines are given to treat HIV/ AIDS patients in some cases. But these medicines are not the proper treatment for this disease.
• It is advised to use effective birth control methods to avoid pregnancy. Some hepatitis drugs can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine.
• It is advised to tell your doctor about all medicines (multivitamins, herbal supplements) you're taking currently before starting your course with hepatitis medicines. There are chances that many drugs can interact, and some drugs should not be used together.
Sofocure V is used to treat patients diagnosed with chronic Hepatitis C virus (HCV) infection. This medicine is usually given in combination with other antiviral medicines.
This medicine works by blocking the virus's NS5A protein, which plays an important role in virus replication.
No, it is advised that Sofocure V should always be used in combination with other antiviral drugs and not as monotherapy.
A person may experience fatigue, headache, nausea, and insomnia. These side effects are mostly observed when this medicine is given in combination with other antiviral medicines.
It is advised to consult your doctor in this case. As Sofocure V may not be safe to take during pregnancy, especially when taken with other antiviral medicines, which can harm the unborn baby.
In patients with compensated cirrhosis or advanced liver disease, Sofocure V Tablet has demonstrated effectiveness in treating hepatitis C. The response rate could differ, though, and it's crucial to closely evaluate liver function both before and after treatment.
The Sofocure V Tablet rarely causes weight gain or reduction as a side effect. Individual reactions to medication, however, can differ. It is advised that you speak with your healthcare practitioner for more evaluation if you undergo therapy and notice any unusual or alarming weight changes.
Patients with a history of liver transplantation who have recurrent hepatitis C may utilize Sofocure V Tablet. However, the particular post-transplantation period and the characteristics of each patient must be taken into account. To choose the best course of treatment, it is advised to speak with a transplant hepatologist or other specialist.
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Author undefined (2025). Real‑world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: A systematic review and meta‑analysis. Frontiers in Gastroenterology.
Cheng PN, Mo LR, Chen CT, Chen CY, Huang CF, Kuo HT, Lo CC, Tseng KC, Huang YH, Tai CM, Peng CY, Bair MJ, Chen CH, Yeh ML, Lin CL, Lin CY, Lee PL, Chong LW, Hung CH, Chang TS, Huang JF, Yang CC, Hu JT, Lin CW, Wang CC, Su WW, Hsieh TY, Lin CL, Tsai WL, Lee TH, Chen GY, Wang SJ, Chang CC, Yang SS, Wu WC, Huang CS, Chou KH, Kao CN, Tsai PC, Liu CH, Lee MH, Cheng CY, Tsai MC, Liu CJ, Dai CY, Lin HC, Kao JH, Chuang WL, Yu ML (2024). TACR investigators. Sofosbuvir/Velpatasvir for Hepatitis C Virus Infection: Real-World Effectiveness and Safety from a Nationwide Registry in Taiwan. Infect Dis Ther.
Devan, P., Tiong, K. L. A., Neo, J. E., Mohan, B. P., Wijarnpreecha, K., Tam, Y. C. S., Wong, Y. J. (2023). Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct‑Acting Antiviral‑Experienced Hepatitis C Virus Patients: A Systematic Review and Meta‑Analysis. Viruses, 15(7), 1489.
Devan, P., Tiong, K. L. A., Neo, J. E., Mohan, B. P., Wijarnpreecha, K., Tam, Y. C. S., Coppola, N., Preda, C. M., & Wong, Y. J. (2023). Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct-Acting Antiviral-Experienced Hepatitis C Virus Patients: A Systematic Review and Meta-Analysis. Viruses, 15(7),
Indian National Association for the Study of the Liver. (2023). Sofosbuvir‑velpatasvir‑voxilaprevir for hepatitis C virus retreatment in difficult‑to‑treat patients: A real‑life observational study from India. (Advance online publication).
Mahmud, S., Hossain, M.B., Haque, E. et al. Effectiveness and safety of sofosbuvir/velpatasvir in chronic hepatitis C virus infection of Bangladeshi children. Egypt Liver Journal 15, 30 (2025)
Rustam, R., Qaisar, A. A systematic review of sofosbuvir/velpatasvir/voxilaprevir in HCV patients previously treated with direct-acting antivirals. Egypt Liver Journal, 14, 67 (2024).
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Written By
Venika Choudhary
Medical Content Writer @ Magicine Pharma
I hold an M.Sc. in Microbiology and have a strong academic foundation in microbial sciences and applied biotechnology. I began my career with extensive hands-on research at CSIR laboratories, focusing on fungal enzyme production, studying fungal diversity in various ecosystems, and developing bio-pesticides as sustainable alternatives to chemical pesticides. This work deepened my understanding of fungal biology, bioactive compounds, and their pharmaceutical and agricultural applications. Transitioning from research, I now work as a medical content writer, where I combine my scientific expertise with a passion for clear and reliable healthcare communication. I apply my research background to create patient-friendly, compliant content for pharmaceutical companies and healthcare platforms, ensuring science is both trustworthy and accessible. Specializing in clear, accurate, and engaging content, I help patients make informed decisions and support pharmaceutical companies in delivering trusted information. Whether writing product descriptions, crafting disease awareness articles, or composing drug information leaflets, I consistently meet regulatory standards and address audience needs, making my content an asset for healthcare brands.