Marketed By
novartis
Pack of
30 tablet
Salt Composition
Pazopanib
Storage
Keep in cold place
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Votrient 400mg Tablet
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Overview
- Soft tissue sarcoma (a tumor that develops in the muscles, joints, organs, tendons, or blood vessels) and kidney cancer (renal cell carcinoma) are treated with Votrient 400mg tablets.
- Pazopanib 400mg is found in Votrient Tablets, which are administered after other therapies have failed. Pazopanib is a member of the class of tyrosine kinase inhibitors.
Indication
- Advanced Renal Cell Carcinoma (RCC)
- Soft Tissue Sarcoma (STS)
Uses
- Advanced Renal Cell Carcinoma (RCC)
- Soft Tissue Sarcoma (STS)
Side Effects
Votrient 400mg tablet has several side effects, which are given below. If the below-mentioned symptoms are seen in the patients and are not tolerable, immediately consult the doctor.
- Bleeding risks
- Headache
- Breathing problem
- Pain in the bone, joints & muscles
- Change in taste
- Hair color change
- Skin pigmentation
- Low appetite
- Irregular heartbeat
- Vomiting
- Diarrhea
- Fatigue
- Nausea
- Hypertension
- Increased sugar levels
- Hepatotoxicity
How To Use
- You have to follow the doctor's prescription strictly for better results.
- Swallow it as a whole.
- Do not chew, crush, or break it.
- Votrient 400mg Tablet is to be taken on an empty stomach.
How It Works
- Votrient (pazopanib) 400 mg works by blocking certain proteins called tyrosine kinases that help tumors grow new blood vessels.
- By inhibiting these pathways, it reduces blood supply to the tumor, slowing its growth and spread.
Safety Advice
Alcohol
CONSULT YOUR DOCTOR
Pregnancy
UNSAFE
Breast Feeding
UNSAFE
Driving
DANGER
Kidney
PRECAUTION
Liver
PRECAUTION
Missed Doses
- In case you missed any dose, consult your doctor.
- Swallow Votrient 400 mg whole on an empty stomach; do not chew, crush, or break the tablet.
- Do not take twice the dose to catch up on the missed dose. This will cause severe side effects and impact your overall health.
FAQs
Votrient 400mg tablet is used to treat advanced kidney cancer and advanced soft tissue sarcomas.
The duration of treatment will depend on the stage of cancer and the overall health of the patients.
Driving and operating heavy machinery is not advisable because this tablet makes you feel dizzy.
Consult your doctor in such cases, as this medicines can harm the newborn baby.
400 mg votrient tablet should be taken orally, once a day, or as directed by your physician. Because breaking or crushing a tablet may change how the medication is absorbed and possibly increase adverse effects, it is vital to swallow the tablet whole with water.
A common adverse effect of Votrient 400mg tablet medication is a change in hair color, which often appears gradually over the course of a few months of treatment. For additional guidance, speak with your physician.
Votrient 400mg Tablet therapies vary from person to person. To assess the treatment's efficacy and establish how long you should take it, your doctor will perform routine examinations.
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References
- Kwon, J. H., Lee, S. E., Choi, J. Y., Kim, H. Y., & Park, S. H. (2024). Real-world outcomes of pazopanib in advanced soft tissue sarcoma: A multicenter study in Korea. Cancer Medicine, 13(5), 2173–2182 - https://pubmed.ncbi.nlm.nih.gov/32607656/
- Ravaud, A., Motzer, R. J., & Sternberg, C. N. (2023). Long-term safety of pazopanib in advanced renal cell carcinoma: A pooled analysis of clinical trial data. Clinical Genitourinary Cancer, 21(2), e137–e145.
- Singh, A., Mehra, N., & Kapoor, A. (2023). Comparative safety and efficacy of pazopanib versus sunitinib in metastatic renal cell carcinoma: A meta-analysis. Journal of Oncology Pharmacy Practice, 29(4), 301–309 - https://pubmed.ncbi.nlm.nih.gov/39257075/
- Tan, A. R., Weiss, G. J., Bilen, M. A., Sonpavde, G., & George, S. (2023). Pharmacokinetics and exposure–response relationship of pazopanib in patients with renal cell carcinoma and sarcoma. Clinical Pharmacokinetics, 62(3), 347–358.
- Van Der Graaf, W. T., Gelderblom, H., & Mathijssen, R. H. J. (2024). Does individualization of pazopanib in soft tissue sarcoma: The case for therapeutic drug monitoring? European Journal of Cancer, 190, 1–9.
- Verheijen, R. B., Lolkema, M. P. J., de Bruijn, P., et al. (2024). Optimizing pazopanib dosing: Evaluation of reduced-dose strategies in oncology patients. British Journal of Clinical Pharmacology, 90(2), 389–400 - https://pmc.ncbi.nlm.nih.gov/articles/PMC5595974/
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