LENALID

Mfd. by :- Natco Pharma (Fulfilled By : Magicine Pharma)

Lenalid

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand name - Lenalid 

Generic name - Lenalidomide 

Innovator brand name - Revlimid 

Manufacturer - Natco Pharma Ltd. 

Salt composition - Lenalidomide 

Storage - Store at room temperature (10-30°C). 

Dosage form - oral (capsule) 

Strength - 5 mg, 10 mg, 15 mg, 25 mg 

Packaging - 30 capsules in a bottle 

Indication - Used in the treatment of multiple myeloma and lepra reaction 

Description 

Lenalid is used in the treatment of multiple myeloma, a type of blood cancer. It enhances the immune system, which indirectly attacks the cancer cells. Lenalidomide prevents the growth of new blood vessels within the tumor. Lenalid works by restricting the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells.  

Lenalid can be taken with or without food. It is advised to take Lenalid at the same time everyday. The capsules should not be opened, broken or chewed. Lenalid is not recommended for use during pregnancy as well as in patients less than 18 years of age. 

Many other medicines can affect or be affected by this medicine. Therefore, make sure to tell your doctor about the medicines you take. 

Ingredients 

The active ingredient in Lenalid is Lenalidomide. 

Pharmacodynamics 

Lenalidomide, a thalidomide analogue, is an immunomodulatory agent possessing immunomodulatory and antiangiogenic properties. Lenalidomide works to inhibit the secretion of pro-inflammatory cytokines and increases the secretion of anti-inflammatory cytokines from peripheral blood mononuclear cells. Lenalidomide inhibits cell proliferation with varying effectiveness (IC50s) in some but not all cell lines. Lenalidomide is effective in inhibiting growth of Namalwa cells (a human B cell lymphoma cell line with a deletion of one chromosome 5) but is much less effective in inhibiting growth of KG-1 cells (human myeloblastic cell line, also with a deletion of one chromosome 5) and other cell lines without chromosome 5 deletions. It does not prolong the QTc interval.  

Effect on cardiac repolarization 

An examination of the effect of lenalidomide on corrected QT (QTc) intervals was conducted in healthy males who received a single oral dose each of 10 mg lenalidomide, 50 mg lenalidomide, 400 mg moxifloxacin (positive control), and placebo, in a random order. As expected, moxifloxacin significantly prolonged QTc. For lenalidomide 10 and 50 mg, the time-matched changes from placebo in the baseline-adjusted least-squares mean QTc were <3 ms, and the upper limit of the two-sided 90 % CI for the change at all timepoints was <10 ms. After lenalidomide administration, no subject underwent a change from baseline >60 ms or QTc >450 ms. Due to such outcomes, the study met the International Conference on Harmonisation (ICH) E14 definition of a negative thorough QT study. Lenalidomide concentrations up to 1522 ng/mL were not associated with QTc changes. The lenalidomide concentration range observed in the QT study was close to that observed in patients receiving lenalidomide doses up to 50 mg, including those with reduced drug clearance associated with RI. Therefore, lenalidomide is not anticipated to prolong QTc intervals in patients receiving therapeutic doses. 

Usage of medicine 

Lenalid is used in the treatment of multiple myeloma and lepra reactions. 

Alternate brands 

  • Lenangio  

  • Lenmid  

  • Kabilen  

  • Laviat  

  • Celomide  

  • Mydolen  

  • Lenalid MF 

Side effects 

Common side effects 

  • Cough  

  • Nausea  

  • Sore throat 

  • Vomiting  

  • Weakness  

  • Dizziness 

  • Fever 

  • Fatigue 

  • Anxiety 

  • Muscle pain 

  • Dry skin  

  • Constipation 

  • Rash  

Serious side effects 

  • Respiratory disorder 

  • Bleeding gums 

  • Blood clots 

  • Decrease in white blood cell count 

  • Sleepiness 

  • Confusion 

  • Tremor  

  • Swelling  

  • Decreased calcium level in blood 

Dosage  

Your healthcare provider will decide your dose according to your medical condition and requirement. 

Warning and precautions 

  • It is not known that it is safe to consume Alcohol with Lenalid capsule. Please consult your healthcare provider for the same. 

  • After taking Lenalid, you may feel sleepy. Therefore, driving or operating machines is not advised. 

  • This medicine is not recommended during pregnancy. 

  • Consult your healthcare provider before taking this medicine. Also, make sure to tell your doctor about the medications you are already taking.  

  • Do not stop consuming this medicine unless your healthcare provider tells you. 

Ques-1 What is Lenalid? 

Ans-1 Lenalid capsule is used in the treatment of multiple myeloma and lepra reactions. 

 

Ques-2 How should I take Lenalid? 

Ans-2 Please contact your healthcare provider for the details of the required dose. 

 

Ques-3 What are the possible side effects of Lenalid? 

Ans-3 The side effects are cough, nausea, vomiting, fever, sore throat, anxiety, muscle pain, constipation and sleepiness. Please consult your healthcare provider if you experience these or any other side effects.  

 

Ques-4 In what strength is it available? 

Ans-4 Lenalid is available in the strengths of 5 mg, 10 mg, 15 mg and 25 mg. Your healthcare provider will decide your dose. 

 

Ques-5  What happens if I miss a dose? 

Ans-5 Take the missed dose as soon as possible. If it is already the time for the next dose, then it is advised to skip the dose. Do not double the dose to catch up. 

 

Ques-6 What should I avoid while consuming this medicine? 

Ans-6 Avoid consuming unpasteurized drinks.  

 

Ques-7 What are self care tips? 

Ans-7 Make healthy choices. Ask your healthcare provider for a proper diet chart. Do not ignore any side effects.  

 

Ques-8 Can I take this medicine during pregnancy? 

Ans-8 This medicine is not recommended during pregnancy. 

 

Ques-9 Can I drive after taking this medicine? 

Ans-9 You may feel sleepy or dizzy after taking Lenalid. Therefore, it is advised not to drive or operate machines. 

 

Ques-10 What are the storage conditions? 

Ans-10 Store at room temperature (10-30°C). 

 

Ques-11 Is this a habit forming medicine? 

Ans-11 No, Lenalid is not a habit forming medicine. 

 

Ques-12 Is Lenalid used to treat mental disorders? 

Ans-12 No, the use of Lenalid is not effective in mental disorders. 

Contraindications  

Do not take Lenalid if you are suffering from any of the following diseases, unless your healthcare provider prescribes: 

  • Heart disease  

  • Kidney disease  

  • Thyroid  

  • Liver disease 

  • Neutropenia  

Make sure to tell your healthcare provider about the medications you already take. 

Above Content has been reviewed by Professionals