Trioday Tablet

Treatment of HIV Infection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Common side effects of Trioday are as follows:

• ​Headache
  
• Dizziness
  
• Drowsiness
  
• Insomnia / Sleeplessness
  
• Abnormal dreams
  
• Impaired concentration
  
• Nausea
  
• Vomiting
  
• Diarrhea
  
• Indigestion / Dyspepsia
  
• Abdominal pain
  
• Bloating / Flatulence
  
• Rash / Skin reactions
  
• Hair loss
  
• Weakness / Fatigue
  
• Fever
  
• Cough
  
• Back pain
  
• Joint pain
  
• Muscle pain
  
• Bone disorders
  
• Anxiety
  
• Depression
  
• Severe mood disturbances
  
• Confusion / Forgetfulness
  
• Seizures / Tremor
  
• Peripheral neuropathy (tingling/numbness in hands and feet)
  
• Severe allergic reactions (wheezing, swelling, swelling, lightheadedness)
  
• Autoimmune disorders
  
• Anemia
  
• Decreased white blood cell count (neutropenia)
  
• Hypercholesterolemia (high cholesterol)
  
• Increased triglycerides
  
• Elevated creatinine kinase
  
• Elevated serum amylase
  
• Increased transaminases (liver enzymes)
  
• Liver toxicity
  
• Kidney damage (including blood in urine)
  
• Lipodystrophy (skin thickening or pits at injection site)
  
• Pneumonia

Take Trioday exactly as prescribed by your doctor, in the recommended dose and duration. Swallow the tablet whole without chewing, crushing, or breaking it, and make sure to take it on an empty stomach.

The Trioday Tablet consists of three medications, namely, efavirenz, lamivudine, and tenofovir disoproxil fumarate. These medications act synergistically to prevent the replication of HIV. Efavirenz acts on the reverse transcriptase enzyme, altering its structure and thus inhibiting its function. Lamivudine and tenofovir act as nucleotide analogs and are incorporated into viral DNA resulting in chain termination and inhibition of further replication. They reduce the viral load of HIV in the body, they help the immune system to recover (by increasing the number of CD4 cells) and they reduce the risk of infections and other complications associated with HIV.

If you miss a dose of Trioday Tablet, take it as soon as you remember. If it’s nearly time for your next scheduled dose, skip the missed one and continue with your regular routine. Do not take two tablets at once to make up for the missed dose.

• Trioday Tablet contains three drugs that retard or stop the progression of HIV.
• The best way to take it is on an empty stomach, preferably in the evening. 
• Do not miss doses, as this may render your treatment ineffective.
• Do not crush, chew, or split the tablet.
• Trioday can make you dizzy or sleepy, so be careful when you are driving or doing anything that needs you to be alert until you know how you react to it.
• It may cause malformations, so avoid pregnancy during and for 12 weeks after taking it.
• Trioday can cause bone weakening; exercise and take calcium and vitamin D supplements.
• The doctor might check your kidney and liver; if you have stomach pain, no appetite, dark urine or yellow eyes or skin, tell your doctor.
• Don't stop Trioday without consulting your doctor.
  

At our pharmacy, your health is our top priority. All of our medicines are safe, effective, and approved by leading health authorities. We partner exclusively with reliable and reputable manufacturers, ensuring the highest quality standards in every product we deliver.

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• Arribas, J. R., et al. (2008). Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: 96-week analysis. Journal of Acquired Immune Deficiency Syndromes, 47(1), 74–78 - https://pubmed.ncbi.nlm.nih.gov/17971715/
  
• Cassetti, I., et al. (2006). The safety and efficacy of tenofovir DF (TDF) + lamivudine (3TC) + efavirenz (EFV) through 5 years in antiretroviral-naïve patients. 8th International Congress on Drug Therapy in HIV Infection, Glasgow, UK - https://pubmed.ncbi.nlm.nih.gov/17621463/
  
• DeJesus, E., et al. (2009). Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral naïve patients: 96-week analysis. Journal of Acquired Immune Deficiency Syndromes, 47(1), 74–78 - https://pubmed.ncbi.nlm.nih.gov/17057609/
  
• Efficacy and Safety of Tenofovir and Lamivudine in Combination with Efavirenz in Patients Co-infected with Human Immunodeficiency Virus and Hepatitis B Virus in China, (n.d.). PubMed. Retrieved from the PubMed database - https://pubmed.ncbi.nlm.nih.gov/26831232/
  
• Gallant, J., et al. (2005). Tenofovir DF (TDF) in combination with lamivudine (3TC) and efavirenz (EFV) in antiretroviral naive HIV infected patients: a 4-year follow-up.
• Pujari, S., Dravid, A., Gupte, N., Joshi, K., & Bele, V. (2008). Effectiveness and safety of a generic fixed-dose combination of tenofovir/emtricitabine/efavirenz in HIV 1 infected patients in Western India. Medscape Journal of Medicine, 10(8), 196.​