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Velasof Tablet

Velasof Tablet

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Salt Composition: Sofosbuvir and Velpatasvir

Expiry Date: 01/2028

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28 tablet

About The Product

Chronic hepatitis C virus (HCV) infection

Velasof Tablet is a viral treatment medication that is used for treating chronic hepatitis C virus infections. This tablet is comprised of two constituents that are sofobuvir and velpatasvir of strength 400mg and 100mg respectively. It helps protect the liver, reduces the risk of cirrhosis and liver cancer, and can cure more than 95 percent of patients. The usual length of treatment is 12 weeks. One tablet is taken each day, with or without food. Side effects can include headache, tiredness, nausea, and sleep problems. Patients should avoid alcohol and tell their doctor about any other health problems or medications they are taking, especially if they have kidney or severe liver problems.

Uses

Chronic hepatitis C virus (HCV) infection

Side Effects

Most side effects of Velasof Tablet do not require medical attention as they may disappear as your body adjusts to the medicine. In case these side effects become worse, consult your doctor immediately.

  • ​Hepatitis B reactivation
  • Severe allergic reactions
  • Headache
  • Dizziness
  • Fatigue / Weakness
  • Nausea
  • Vomiting
  • Insomnia (difficulty sleeping)
  • Diarrhea
  • Constipation
  • Itching (pruritus)
  • Decreased appetite
  • Muscle or joint pain
  • Rash
  • Fever
  • Anemia (low red blood cells)
  • Neutropenia (low white blood cells)
  • Breathing problems / Difficulty breathing
  • Cough
  • Bone pain
  • Slow heart rate

Dosage and Administration

  • Take the Velasof Tablet exactly as your healthcare provider suggests you.
  • Do not alter the dose strength unless your doctor asks you to do so.

Mechanism of action

Velasof Tablet is a combination of two antiviral medicines, such as Sofosbuvir and Velpatasvir. It works by blocking the replication of the virus to reduce its levels in the body.

By suppressing viral replication, it helps to slow down the progression of liver damage and clear up the infection.

Safety Advice

Alcohol
When on Velasof therapy for treatment of hepatitis C, alcohol should be avoided completely. Alcohol is known to worsen liver conditions and may possibly interfere with the efficacy of the drug. You should discuss this with your healthcare provider.
Pregnancy
There is insufficient data to demonstrate the safety of Velasof in pregnancy. Pregnant women or those who want to get pregnant should take advice from their doctors before taking this tablet. Your doctor will think about how the possible benefits and harms of this may affect your condition.
Breast Feeding
There is insufficient data to demonstrate the safety of Velasof in breastfeeding. Breastfeeding women should take advice from their doctors before taking this tablet. Your doctor will think about how the possible benefits and harms of this may affect your condition.
Driving
It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of the medicine.
Kidney
Do not take Velasof Tablet without a doctor's consultation in case of kidney problems.
Liver
Share your medical history with the doctor in case of liver disease before taking this medicine.

Missed Doses

  • If you miss a dose of Velasof Tablet, take it as soon as you remember.
  • However, if it is already time for the next dose, please contact your healthcare provider.
  • Do not double the dose.

Quick Tips

  • Tests for hepatitis B before starting treatment to reduce the risk of HBV reactivation.

  • Velasof must not be combined with amiodarone, risk of fatal bradycardia.

  • May cause fatigue, dizziness, or blurred vision; avoid driving or tasks needing focus until you know how it affects you.

  • Headaches are common; drink plenty of water and use a suitable painkiller; inform your doctor if they are persistent.

  • Liver function and viral load should be monitored regularly during treatment.

FAQs

​Velasof is a combination used in the treatment of chronic hepatitis C virus infection.​

References

  • De Avelar, C. R., Nunes, B. V. C., da Silva Sassaki, B., Vasconcelos, M. D. S., de Oliveira, L. P. M., Lyra, A. C., Bueno, A. A. (2023). Efficacy of silymarin in patients with non‑alcoholic fatty liver disease—the SILIVER trial: a randomized controlled clinical trial protocol. Trials, 24(177). https://doi.org/10.1186/s13063-023-07210-6
  • Imam, S. S., Alshammari, S. O., Alshehri, S., Mahdi, W. A., & Al‑Agamy, M. H. (2024). Formulation of silymarin surface‑modified vesicles: in vitro characterization to cell viability assessment. Saudi Pharmaceutical Journal, 32(6), 102072. https://doi.org/10.1016/j.jsps.2024.102072
  • Navarro, V. J., Belle, S. H., D’Amato, M., Adfhal, N., Brunt, E. M., Fried, M. W., Harrison, S. (2019). Silymarin in non‑cirrhotics with non‑alcoholic steatohepatitis: a randomized, double‑blind, placebo‑controlled trial. PLoS One, 14(9), e0221683. https://doi.org/10.1371/journal.pone.0221683

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