Sofovir 400mg Tablet
Prescription Required
Manufactured By
Hetero Healthcare Ltd
Pack of
28 tablet
Salt Composition
Sofosbuvir 400mg
Storage
Keep in cold place
Delivering To:
All Substitutes
Overview
Sofosbuvir 400mg tablet is used with other medications in the treatment of chronic (long-lasting) hepatitis C virus (HCV) infection in adults. It is an antiviral medicine that lowers the amount of virus in the body and works to eliminate the virus over some time.
Indication
Hepatitis C
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Description
Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability. By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation. Dephosphorylation tends to create the inactive metabolite GS-331077. The half-life of Sofosbuvir is 0.4 hours, and the half-life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofosbuvir, 80% is normally excreted in the urine, 2.5% in expired air recovery, and 14% in feces.
Side Effects
Sofosbuvir 400mg tablet may cause some serious and unwanted side effects that require immediate medical attention otherwise it can also lead to higher risk. Do not forget to discuss the risks and benefits of this medication with your doctor.
Insomnia
Nausea
Fainting
Neutropenia (low white blood cell count)
Chills
Fatigue
Headache
Loss of appetite
Weakness
Skin rash
Itching
Irritability
Joint pain
Fever
How To Use
Do not crush, chew, or break the tablet. Take the same dose as prescribed by your healthcare provider.
Please seek emergency medical attention in case of overdose.
Safety Advice
Alcohol
unsafe
It is advisable not to consume alcohol while taking this medicine.
Pregnancy
consult your doctor
Do not take Sofosbuvir 400mg tablet without consulting the doctor, in case of pregnancy.
Breast Feeding
consult your doctor
Without a doctor's consultation, do not take this medicine if you're breastfeeding.
Driving
danger
It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of the medicine.
Kidney
caution
Do not take Sofosbuvir 400mg tablet without a doctor's consultation in case of kidney problems.
Liver
caution
Share your medical history with the doctor in case of liver disease before taking this medicine.
Missed Doses
In case of a missed dose, take the medicine as soon as you remember. However, if it is already time for the next dose, do not take the previous dose. Skip it and take the scheduled dose. Also, tell your healthcare provider about the same.
FAQs
Sofosbuvir tablet is an antiviral medicine. It is used with other medicines to treat chronic (long-lasting) hepatitis C virus (HCV) infection in adults.
Do not crush, chew, or break the tablet. Take it exactly as your healthcare provider tells you.
Store at room temperature (10-30°C). Keep it covered, and away from children, direct light, heat, and moisture.
There can be some side effects of Sofovir such as fever, headache, irritability, anemia, fatigue, and diarrhea. Nausea and skin rash. Kindly consult your healthcare provider if you experience these or any other side effects.
Do not drive or operate heavy machines in case you feel unwell after taking this medicine.
