SOFOVIR

Mfd. by :- Hetero Drugs Ltd. (Fulfilled By : Magicine Pharma)

sofovir

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Medicine details

Brand name - Sofovir
Generic name - Sofosbuvir
Manufacturer - Hetero Drugs Ltd.
Salt composition - Sofosbuvir 400mg
Storage - Store at room temperature (10-30°C)
Dosage form - Oral (tablet)
Strength - 400mg
Packaging - Bottle of 28 tablets
Gender - Unisex
Prescription required - Yes
Indication - used in the treatment of chronic hepatitis C virus (HCV) infection

Description

Sofovir (Sofosbuvir 400mg) is used with other medications in the treatment of chronic (long-lasting) hepatitis C virus (HCV) infection in adults. It is an antiviral medicine that lowers the amount of virus in the body and works to eliminate the virus over a period of time.

Pharmacodynamics 

Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability. By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation. Dephosphorylation tends to create the inactive metabolite GS-331077. The half life of Sofosbuvir is 0.4 hours, and the half life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofosbuvir, 80% is normally excreted in urine, 2.5% in expired air recovery and 14% in feces.

Ingredients 

The active ingredient of Sofovir tablets is Sofosbuvir 400mg.

Usage of medicine 

Sofovir (Sofosbuvir) 400mg tablet is an antiviral medicine. It is used with other medicines to treat chronic (long-lasting) hepatitis C virus (HCV) infection in adults.

 

Side effects

Common side effects 

  • Fever

  • Chills

  • Fatigue

  • Headache 

  • Loss of appetite

  • Weakness

  • Skin rash

  • Itching

  • Irritability 

  • Joint pain

Serious side effects

  • Anemia

  • Insomnia

  • Nausea

  • Fainting 

  • Neutropenia (low white blood cell count)

Dosage 

Normal dose 

Do not crush, chew or break the tablet. Take the same dose as prescribed by your healthcare provider.

Missed dose 

In case of a missed dose, take the medicine as soon as you remember. However, if it is already the time for the next dose, do not take the previous dose. Skip it and take the scheduled dose. Also, tell your healthcare provider about the same.

Overdose

Please seek emergency medical attention.

 

Warning and precautions 

  • Be sure to tell your healthcare provider about your medical history and the list of medications you already take.

  • Avoid the consumption of alcohol, fatty and sugary foods.

  • During pregnancy, make sure to ask your healthcare provider before the consumption of Sofovir 400mg tablets.

  • Sofovir 40mg (Sofosbuvir) is safe for consumption, only if prescribed by the doctor. Therefore, ask your healthcare provider about the consumption of this medicine during breastfeeding.

  • In patients with liver or kidney disease, Sofovir should be administered with caution.

  • Avoid driving and operating heavy machines, if you feel unwell after taking Sofovir 400mg tablet.

  • Do not alter or increase the dose strength, unless your healthcare provider tells you.

  • Do not stop taking Sofovir, unless your healthcare provider tells you.

FAQs

Q1- What is Sofovir?

A- Sofovir (Sofosbuvir) 400mg tablet is an antiviral medicine. It is used with other medicines to treat chronic (long-lasting) hepatitis C virus (HCV) infection in adults.

Q2- How should I take a Sofovir tablet?

A- Do not crush, chew or break the tablet. Take it exactly as your healthcare provider tells you. 

Q3- In what strength is Sofovir (Sofosbuvir) available?

A- Sofovir tablets are available in the strength of 400mg.

Q4- What are the storage conditions for Sofovir tablets?

A- Store at room temperature (10-30°C). Keep it covered, and away from children, direct light, heat and moisture. 

Q5- What are the possible side effects of Sofovir?

A- There can be some side effects of Sofovir such as fever, headache, irritability, anemia, fatigue, diarrhea. nausea and skin rash. Kindly consult your healthcare provider if you experience these or any other side effects.

Q6- Can I drive after taking this medicine?

A- Do not drive or operate heavy machines in case you feel unwell after taking this medicine.

Q7- Can I take this medicine in kidney disease?

A- In patients with kidney disease, Sofovir 400mg tablets should be administered with caution. Dose adjustment may be needed. Please contact your healthcare provider for the same.

Q8- What should be done in case of overdose?

A- It is advised to seek emergency medical help in case of overdose.

Q9- What if I miss a dose?

A- In such a case, skip the previous dose if it is already the time for the next scheduled dose. Do not double the dose to catch up.

Q10- What should I avoid while taking this medicine?

A- Consume a well balanced diet, avoiding sugary foods.

Q11- Is consumption of alcohol safe with this medicine?

A- Reaction of Sofovir with alcohol is not known. Please consult your healthcare provider.

Q12- Is it a habit forming medicine?

A- It is not a habit forming medication.

Q13- Can I take this medicine during pregnancy?

A- During pregnancy, take this medicine only if your healthcare provider tells you.

Q14- Can I take this medicine during breastfeeding?

A- Take this medicine only if prescribed by a healthcare provider.

Q15- Can I take this medicine in liver disease?

A- Before taking this medicine in liver disease, make sure to contact your healthcare provider for proper guidance.

 

Above Content has been reviewed by Professionals